Selective Limbic Blood–Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies
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چکیده
منابع مشابه
Selective Limbic Blood–Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies
Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC) complex. Recently, we showed that a feline model of limbic encephalitis with LGI1 antibodies, called feline complex partial seizures with orofacial involvement (F...
متن کاملHyponatraemia caused by LGI1-associated limbic encephalitis
Limbic encephalitis (LE), once thought to be a rare paraneoplastic phenomenon, is increasingly diagnosed in patients without malignancy. Autoimmune LE has emerged as a distinct clinical entity. Autoantibodies to neuronal cell surface proteins have been described and may now be tested for. This has led to an exponential increase in the number of cases being reported. The most recently implicated...
متن کاملAnti-LGI1 Limbic Encephalitis—Case Report
Limbic encephalitis is characterized by acute or subacute changes in mood and behaviour, by recent memory changes, seizures and cognitive dysfunction. In this article, the authors present a case report of a 53-year-old woman that resorted to consultation with clinical presentation suggestive of major depressive episode. However, the worsening of symptoms despite treatment and the testimony of s...
متن کاملClinical features of limbic encephalitis with LGI1 antibody
OBJECTIVE The objective of this study was to analyze the clinical manifestation, course, evolution, image manifestation, and treatments of LGI1 limbic encephalitis (LE). PATIENTS AND METHODS Studies confirmed that LE with the complex antibody of voltage-gated potassium channels is LGI1 LE. Since then, LE cases have been reported. In this study, 10 typical LE cases were searched in PubMed. The...
متن کاملA rare case of limbic encephalitis with anti leucine-rich glioma inactivated-1 (LGI1) antibodies.
We report a case of limbic encephalitis with LGI1 antibodies and cranial MRI abnormality. A 41-year-old woman who presented with confusional state that had started 1 month ago. Brain magnetic resonance imaging revealed hyperintense signal in right basal ganglia followed by hyperintense signals in left hippocampus and bilateral basal ganglia half a month later. This case expands the spectrum of ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01364